Bruxism can be induced by several psychotropic drugs like antidepressants, antipsychotics and amphetamines. Several cases of drug-induced bruxism who were treated with buspirone were reported but there is a only a case report and a clinical trial for treatment of bruxism with gabapentin. We report here a case of bruxism induced by şuoxetine and treated by gabapentin. A 43-year-old woman was using şuoxetine 20 mg, for major depression and generalized anxiety disorder. She was also diagnosed with OCPD. Her symptoms improved but she reported severe bruxism symptoms during night and day. She had severe teeth grinding, clenching, jaw pain and temporal headache. She was experiencing difficulties opening her mouth in the mornings. Referring to the prior case reports, she was given buspirone 10 mg/day bid for 2 weeks but significant improvement was not observed. She also reported Restless Legs Syndrome (RLS) symptoms such as paresthesia and pain. Gabapentin was started with titration and increased to a final dose of 300 mg. After 5 days of the treatment, she reported full remission. RLS symptoms also improved. She reported only minimal dizziness as a side effect and she was very satisfied with her treatment. She was also referred to the group treatment for bruxism and comorbid disorders. Gabapentin may be an effective treatment option for bruxism with its anxiolytic, antispasmodic effects. Gabapentin also increases sleep quality and it is also a treatment option for comorbid restless legs syndrome.