Psychiatry and Clinical Psychopharmacology
Original Article

Resting-State Functional Connectivity Alterations in Drug-Naive Adolescents with Obsessive-Compulsive Disorder

1.

Child and Adolescent Psychiatry Department, Istanbul University School of Medicine, İstanbul, Turkey

2.

Hulusi Behçet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, Istanbul, Turkey

3.

Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University İstanbul, Turkey

4.

Department of Physiology, Istanbul University School of Medicine, İstanbul, Turkey

Psychiatry and Clinical Psychopharmacology 2021; 31: 40-47
DOI: 10.5152/pcp.2021.20169
Read: 1605 Downloads: 36 Published: 01 April 2021

Objective: It is known that there are alterations in functional brain networks in pediatric obsessive-compulsive disorder (OCD) and new studies are needed to identify and conceptualize these alterations. This study aimed to investigate resting-state functional connectivity (Rs-FC) changes in adolescents with OCD.

Materials and Methods: We compared FC alterations in 15 drug-naive adolescents with OCD and 15 healthy controls (HC). Rs-FC networks were obtained with independent component analysis and logistic regression was used to identify the components that displayed significant group differentiation.

Results: Data were decomposed into 30 independent components, and 4 components corresponding to functional networks showed a significant difference between the 2 groups (sensitivity and specificity value was 86.7%): Posterior cingulate cortex (PCC), cerebellum, right frontoparietal network (R-FPN), and anterior DMN (aDMN). The expression scores of the PCC, cerebellum, and R-FPN were significantly lower in OCD, while the expression score of the aDMN was significantly higher in OCD as compared with HC. In addition, OCD patients demonstrated a significant anti-correlation between the R-FPN and lateral sensorimotor network, and a positive correlation between the PCC and parahippocampal gyri.

Conclusion: These findings indicate that alterations in FC networks incumbent on high mental processes are involved in the pathophysiology of OCD in adolescents.

Cite this article as: Kınay D, Ulasoglu Yildiz C, Kurt E, Eryurek K, Demiralp T, Coşkun M. Resting-state functional connectivity alterations in drug-naive adolescents with obsessive-compulsive disorder. Psychiatr Clin Psychopharmacol. 2021; 31: 40-47.

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