Risperidone is an atypical antipsychotic agent, which blocks D2 and 5HT2 receptors. The most commonly reported side effects associated with risperidone are increased appetite, weight gain and sedation. Incidence of risperidone-induced enuresis is less than 1%. It is described in the literature that the concomitant use of risperidone with selective serotonin reuptake inhibitors and mood stabilizing drugs may cause nocturnal enuresis. The Case is a 35-year-old male patient admitted to our hospital because of jalustik delusions, which lasted approximately one year. His thought was about his wife’s cheating him with another man. In the mental status examination there were no other delusions or hallucinations. According to DSM-IV-TR criteria delusional disorder was diagnosed, and risperidone 2 mg / day was started. 20 days later, the patient called to check the appointment. He was better but he had urinary incontinence symptoms 4-5 times per week. According to the urology and internal medicine consultations, no pathology was detected. It was thought that risperidone was liable for the status of nocturnal enuresis. It was seen that after substitute risperidone with aripiprazole, enuresis ceased rapidly. In this case nocturnal enuresis emerged with the use of risperidone and ceased rapidly after discontinuation of risperidone. The pathophysiology of antipsychotic-induced enuresis is not clear. Central dopamine blockade and peripheral ?1-adrenergic blockade have been suggested to play a role in relaxation of the urethral muscles. Another mechanism is the blockage of pudendal reşexes via antagonism of 5-HT2 and 5-HT3. Perhaps a low affinity for muscarinic receptors, strong peripheral alpha-1 adrenergic, central dopaminergic, and norepinephrine blocking effect of risperidone causes enuresis. Considering the effect of the enuresis nocturna on quality of life, clinicians should be more vigilant about presence for this side effect.